About 100km from Yerevan, Vayots Dzor is about two hours from the capital of Armenia.
The easiest way to get to Yerevan is either a bus or a private car. A taxi can be arranged easily from Yerevan, but try not to hail a taxi because you might be charged a higher rate. It is easy to arrange a taxi with mobile applications such as GG taxi, U taxi or Yandex taxi. In addition, there are many public buses that depart from Yerevan to Yeghegnadzor each day. There is no train connecting Vayots Dzor to Yerevan.
You may also rent a car in Yerevan and drive to Vayots Dzor yourself. The roads here are well-maintained, and renting a car gives you more freedom to drive through the region and see its stunning landscape filled with vineyards and orchards. Most car rental companies have fixed prices depending on the total number of days you want to rent the car.
To give an estimate, you could expect to spend around 50,000 AMD to rent a Toyota RAV4 for 1-2 days. If you rent a car for a longer amount of time, the price decreases, which would bring the rate for the same car to 43,500 AMD for 3-4 days.
The following table shows the distances and time it will take you to arrive from Yerevan to the main tourism destinations in Vayots Dzor and approximate taxi price estimates.